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Summary

Aspergillosis is a disease caused by a fungus (or mold) called Aspergillus. The fungus is very common in both indoors and outdoors. Most people breathe in the spores of the fungus every day without being affected. But some people get the disease. It usually occurs in people with lung diseases or weakened immune systems.

There are different kinds of aspergillosis. One kind is allergic bronchopulmonary aspergillosis (also called ABPA). Symptoms of ABPA include wheezing and coughing. ABPA can affect healthy people but it is most common in people with asthma or cystic fibrosis.

Another kind is invasive aspergillosis, which damages tissues in the body. It usually affects the lungs. Sometimes it can also cause infection in other organs and spread throughout the body. It affects people who have immune system problems, such as people who have had a transplant, are taking high doses of steroids, or getting chemotherapy for some cancers.

Your doctor might do a variety of tests to make the diagnosis, including a chest x-ray, CT scan of the lungs, and an examination of tissues for signs of the fungus. Treatment is with antifungal drugs. If you have ABPA, you may also take steroids.

Centers for Disease Control and Prevention

Start Here

• Aspergillosis (American Thoracic Society) - PDF Also in Spanish
• Aspergillosis Basics (Centers for Disease Control and Prevention) Also in Spanish

Symptoms

• Symptoms of Aspergillosis (Centers for Disease Control and Prevention)

Diagnosis and Tests

• Fungal Culture Test (National Library of Medicine) Also in Spanish

Prevention and Risk Factors

• Reducing Risk for Aspergillosis (Centers for Disease Control and Prevention)

Related Issues

• Aspergillus and Allergic Bronchopulmonary Aspergillosis (Cystic Fibrosis Foundation)

Specifics

• Allergic Bronchopulmonary Aspergillosis (ABPA) (American Academy of Allergy, Asthma, and Immunology) Also in Spanish

Clinical Trials

• ClinicalTrials.gov: Aspergillosis (National Institutes of Health)
• ClinicalTrials.gov: Aspergillosis, Allergic Bronchopulmonary (National Institutes of Health)

Journal Articles References and abstracts from MEDLINE/PubMed (National Library of Medicine)

• Article: Pyroptosis Mediated by ROS/Caspase-3/GSDME Pathway in Aspergillus fumigatus-Induced Fungal Keratitis.
• Article: Fusarium spp. and Aspergillus flavus infection induces pathogen-specific and pathogen-independent host...
• Article: HIF-1α Promotes Inflammatory Responses in Aspergillus Fumigatus Keratitis by Activating Pyroptosis...
• Aspergillosis -- see more articles

Find an Expert

• Centers for Disease Control and Prevention Also in Spanish
• National Institute of Allergy and Infectious Diseases

Children

• Aspergillosis (American Academy of Pediatrics) Also in Spanish

Patient Handouts

• Aspergillosis (Medical Encyclopedia) Also in Spanish
• Aspergillosis precipitin (Medical Encyclopedia) Also in Spanish
• Pulmonary aspergilloma (Medical Encyclopedia) Also in Spanish