Health Topics
Official websites use .gov
A
.gov website belongs to an official government
organization in the United States.
Secure .gov websites use HTTPS
A
lock (
) or https:// means you’ve safely connected to
the .gov website. Share sensitive information only on official,
secure websites.
Overview
A plaque is an abnormal cluster of protein fragments. Such clusters can be found between nerve cells in the brain of someone with Alzheimer. A microscope will also show damaged nerve cells. In them are tangles called neurofibrillary tangles. These consist of twisted strands of a different protein.
Together, the plaque and tangles cause structural and chemical problems. It appears that Alzheimer disease causes parts of the brain that normally work together to disconnect.
Review Date 3/31/2024
Updated by: Joseph V. Campellone, MD, Department of Neurology, Cooper Medical School at Rowan University, Camden, NJ. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.