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Hereditary amyloidosis is a condition in which abnormal protein deposits (called amyloid) form in almost every tissue in the body. Harmful deposits most often form in the heart, kidneys, and nervous system. These protein deposits damage the tissues and interfere with how organs work.
Causes
Hereditary amyloidosis is passed down from parents to their children (inherited). Genes may also play a role in primary amyloidosis.
Other types of amyloidosis are not inherited. They include:
- Senile systemic: seen in people older than 70
- Spontaneous: occurs without a known cause
- Secondary: results from diseases such as cancer of certain blood cells (myeloma)
Specific conditions include:
Treatment
Treatment to improve the function of damaged organs will help relieve some symptoms of hereditary amyloidosis. A liver transplant may be helpful to reduce the creation of harmful amyloid proteins. Talk to your health care provider about treatments.
Alternative Names
Amyloidosis - hereditary; Familial amyloidosis
Images
References
Gertz MA, Dispenzieri A. Amyloidosis. In: Goldman L, Cooney KA, eds. Goldman-Cecil Medicine. 27th ed. Philadelphia, PA: Elsevier; 2024:chap 174.
Lachmann HJ, Sharpley FA. Amyloidosis. In: Firestein GS, Budd RC, Gabriel SE, Koretzky GA, McInnes IB, O'Dell JR, eds. Firestein & Kelley's Textbook of Rheumatology. 11th ed. Philadelphia, PA: Elsevier; 2021:chap 123.
Review Date 11/19/2023
Updated by: Jacob Berman, MD, MPH, Clinical Assistant Professor of Medicine, Division of General Internal Medicine, University of Washington School of Medicine, Seattle, WA. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.