Infectious esophagitis is rare. It often occurs in people with weak immune systems. People who have strong immune systems don't usually develop the infection.

Common causes of a weakened immune system include:

• HIV/AIDS
• Chemotherapy
• Diabetes
• Leukemia or lymphoma
• Medicines that suppress the immune system, such as ones given after organ or bone marrow transplant
• Other conditions that suppress or weaken your immune system

Organisms (germs) that cause esophagitis include fungi, yeast, and viruses. Common organisms include:

• Candida albicans and other Candida species
• Cytomegalovirus (CMV)
• Herpes simplex virus (HSV)
• Human papillomavirus (HPV)
• Tuberculosis bacteria (Mycobacterium tuberculosis) -- not common

Symptoms of infectious esophagitis include:

• Difficulty swallowing
• Painful swallowing
• Fever and chills
• Yeast infection of the tongue and lining of the mouth (oral thrush)
• Sores in the mouth or back of the throat (with herpes or CMV)

Your health care provider will ask about your symptoms and examine your mouth and throat. Tests may include:

• Blood and urine tests for CMV
• Culture of cells from the esophagus for herpes or CMV
• Mouth or throat swab culture for candida

You may need to have an upper endoscopy exam. This is a test to examine the lining of the esophagus.

Most often, medicines can control the infection. The type of medicine given will depend on the cause of the infection.

Antiviral medicines can treat a herpes infection. Common antiviral medicines for a herpes infection are:

• Acyclovir
• Famciclovir
• Valacyclovir

Antifungal medicines can treat candida infection. Common antifungal medicines are:

• Fluconazole (taken by mouth)
• Caspofungin (given by injection)
• Amphotericin (given by injection)

Antiviral medicines can treat CMV infection. Ganciclovir or foscarnet are given through a vein (intravenously). In some cases, a medicine called valganciclovir, which is taken by mouth, can be used for CMV infection.

Some people may also need pain medicine.

Ask your provider for special diet recommendations. For example, there may be foods you need to avoid eating as your esophagitis heals.

Many people need other long-term medicines to suppress the virus or fungus and to prevent the infection from coming back.

In people with a healthy immune system, esophagitis often goes away on its own. People with a weak immune system may take longer to get better.

Health problems that may result from infectious esophagitis include:

• Holes in your esophagus (perforations)
• Infection at other sites
• Recurrent infection

Contact your provider if you have any condition that can cause reduced immune response and you develop symptoms of infectious esophagitis.

If you have a weak immune system, try to avoid contact with people who have an infection with any of the organisms mentioned above.

Infection - esophagus; Esophageal infection

Graman PS. Esophagitis. In: Bennett JE, Dolin R, Blaser MJ, eds. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 9th ed. Philadelphia, PA: Elsevier; 2020:chap 97.

Katzka DA. Esophageal disorders caused by medications, trauma, and infection. In: Feldman M, Friedman LS, Brandt LJ, eds. Sleisenger and Fordtran's Gastrointestinal and Liver Disease. 11th ed. Philadelphia, PA: Elsevier; 2021:chap 45.

Updated by: Jatin M. Vyas, MD, PhD, Associate Professor in Medicine, Harvard Medical School; Associate in Medicine, Division of Infectious Disease, Department of Medicine, Massachusetts General Hospital, Boston, MA. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.