Autonomic neuropathy has a group of symptoms. It is not a specific disease. There are many causes.

Autonomic neuropathy involves damage to the nerves that carry information from the brain and spinal cord. The information is then carried to the heart, blood vessels, bladder, intestines, sweat glands, and pupils.

Autonomic neuropathy may be seen with:

• Alcohol overuse
• Diabetes (diabetic neuropathy)
• Disorders involving scarring of tissues around the nerves
• Guillain Barré syndrome or other diseases that inflame nerves
• HIV/AIDS
• Inherited nerve disorders
• Multiple sclerosis
• Parkinson disease
• Spinal cord injury
• Surgery or injury involving the nerves

Symptoms vary, depending on the nerves affected. They usually develop slowly over years.

Stomach and intestine symptoms may include:

• Constipation (hard stools)
• Diarrhea (loose stools)
• Feeling full after only a few bites (early satiety)
• Nausea after eating
• Problems regulating and controlling bowel movements
• Swallowing problems
• Swollen abdomen
• Vomiting of undigested food

Heart and lungs symptoms may include:

• Abnormal heart rate or rhythm
• Blood pressure drop with position that causes dizziness when standing
• High blood pressure
• Shortness of breath with activity or exercise

Bladder symptoms may include:

• Difficulty beginning to urinate
• Feeling of incomplete bladder emptying
• Leaking urine

Other symptoms may include:

• Sweating too much or not enough
• Heat intolerance brought on with activity and exercise
• Sexual problems, including erection problems in men and vaginal dryness and orgasm difficulties in women
• Abnormal pupil reaction in one or both eyes or trouble adjusting to bright lights
• Weight loss without trying

Signs of autonomic nerve damage are not always seen when your health care provider examines you. Your blood pressure or heart rate may change when lying down, sitting, or standing.

Special tests to measure sweating and heart rate may be done. This is called autonomic nervous system testing.

Other tests depend on what type of symptoms you have.

Treatment to reverse nerve damage is most often not possible. As a result, treatment and self-care are focused on managing your symptoms and preventing further problems.

Your provider may recommend:

• Extra salt in the diet or taking salt tablets to increase fluid volume in blood vessels
• Fludrocortisone or similar medicines to help your body retain salt and fluid
• Medicines to treat irregular heart rhythms
• Pacemaker
• Sleeping with the head raised
• Wearing compression stockings

The following may help your intestines and stomach work better:

• Daily bowel care program
• Medicines that help the stomach move food through faster
• Sleeping with the head raised
• Small, frequent meals

Medicines and self-care programs can help you if you have:

• Urinary incontinence
• Neurogenic bladder
• Erection problems
• Stool incontinence
  

How well you do will depend on the cause of the problem and if it can be treated.

Contact your provider if you have symptoms of autonomic neuropathy. Early symptoms might include:

• Becoming faint or lightheaded when standing
• Changes in bowel, bladder, or sexual function
• Unexplained nausea and vomiting when eating

Early diagnosis and treatment may control symptoms.

Autonomic neuropathy may hide the warning signs of a heart attack. Instead of feeling chest pain, if you have autonomic neuropathy, during a heart attack you may only have:

• Sudden fatigue
• Sweating
• Shortness of breath
• Nausea and vomiting

Prevent or regulate associated disorders to reduce the risk for neuropathy. For example, people with diabetes should closely regulate blood sugar levels.

Neuropathy - autonomic; Autonomic nerve disease

Katirji B. Disorders of peripheral nerves. In: Jankovic J, Mazziotta JC, Pomeroy SL, Newman NJ, eds. Bradley and Daroff's Neurology in Clinical Practice. 8th ed. Philadelphia, PA: Elsevier; 2022:chap 106.

Smith G, Shy ME. Peripheral neuropathies. In: Goldman L, Cooney KA, eds. Goldman-Cecil Medicine. 27th ed. Philadelphia, PA: Elsevier; 2024:chap 388.

Updated by: Joseph V. Campellone, MD, Department of Neurology, Cooper Medical School at Rowan University, Camden, NJ. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.