The mediastinum is the part of the chest that lies between the sternum and the spinal column, and between the lungs. This area contains the heart, large blood vessels, windpipe (trachea), thymus gland, esophagus, and connective tissues. The mediastinum is divided into three sections:

• Anterior (front)
• Middle
• Posterior (back)

Mediastinal tumors are rare.

The most common location for tumors in the mediastinum depends on the age of the person. In children, tumors are more common in the posterior mediastinum. These tumors often begin in the nerves and are noncancerous (benign).

Most mediastinal tumors in adults occur in the anterior mediastinum. They are usually cancerous (malignant) lymphomas, germ cell tumors, or thymomas (cancers of the thymus). These tumors are most common in middle aged and older adults.

Almost one half of mediastinal tumors cause no symptoms and are found on a chest x-ray done for another reason. Symptoms that do occur are due to pressure on (compression of) local structures and may include:

• Chest pain
• Fever and chills
• Cough
• Coughing up blood (hemoptysis)
• Hoarseness
• Night sweats
• Shortness of breath

A medical history and physical exam may show:

• Fever
• High-pitched breathing sound (stridor)
• Swollen or tender lymph nodes (lymphadenopathy)
• Unintentional weight loss
• Wheezing

Further tests that may be done include:

• Chest x-ray
• CT-guided needle biopsy
• CT scan of the chest
• Mediastinoscopy with biopsy
• MRI of the chest

Treatment for mediastinal tumors depends on the type of tumor and symptoms:

• Thymomas are treated with surgery. It may be followed by radiation or chemotherapy, depending on the stage of the tumor and the success of the surgery.
• Germ cell tumors are usually treated with chemotherapy.
• For lymphomas, chemotherapy is the treatment of choice, and is possibly followed by radiation.
• For nerve-related tumors of the posterior mediastinum, surgery is the main treatment.

The outcome depends on the type of tumor. Different tumors respond differently to chemotherapy and radiation.

Complications of mediastinal tumors include:

• Spinal cord compression
• Spread to nearby structures such as the heart, lining around the heart (pericardium), and great vessels (aorta and vena cava)

Radiation, surgery, and chemotherapy can all have serious complications.

Contact your health care provider if you notice symptoms of a mediastinal tumor.

Thymoma - mediastinal; Lymphoma - mediastinal

McCool FD. Diseases of the diaphragm, chest wall, pleura, and mediastinum. In: Goldman L, Cooney KA, eds. Goldman-Cecil Medicine. 27th ed. Philadelphia, PA: Elsevier; 2024:chap 86.

Triplette M, Varghese TK, Cheng GS. Mediastinal tumors and cysts. In: Broaddus VC, Ernst JD, King TE, et al, eds. Murray and Nadel's Textbook of Respiratory Medicine. 7th ed. Philadelphia, PA: Elsevier; 2022:chap 115.

Updated by: Todd Gersten, MD, Hematology/Oncology, Florida Cancer Specialists & Research Institute, Wellington, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.