Tetrahydrozoline

Tetrahydrozoline is sold under the following brand names:

• Eye-Sine
• Geneye
• Murine Tears Plus
• Opti-Clear
• Optigene 3
• Tyzine
• Visine Original and Advanced Relief

Note: This list may not be all inclusive.

While poisoning symptoms are uncommon after applying the drops to the eyes, these agents can produce significant poisoning if taken orally.

Symptoms may include:

• Altered mental state
• Coma (lack of responsiveness)
• Difficulty breathing or no breathing
• Blurred vision
• Blue lips and fingernails (cyanosis)
• Changes in blood pressure (high at first, low later)
• Change in pupil size
• Fast or slow heartbeat
• Headache
• Irritability
• Low body temperature
• Nausea and vomiting
• Nervousness, tremors
• Seizures
• Weakness

Seek medical help right away. DO NOT make a person throw up unless told to do so by poison control or a health care professional.

The following information is helpful for emergency assistance:

• The patient's age, weight, and condition
• The name of the product (ingredients and strength if known)
• The time it was swallowed
• The amount swallowed

However, DO NOT delay calling for help if this information is not immediately available.

Your local poison control center can be reached directly by calling the national toll-free Poison Help hotline (1-800-222-1222) from anywhere in the United States. This national hotline will let you talk to experts in poisoning. They will give you further instructions.

This is a free and confidential service. All local poison control centers in the United States use this national number. You should call if you have any questions about poisoning or poison prevention. It does NOT need to be an emergency. You can call for any reason, 24 hours a day, 7 days a week.

Take the container with you to the hospital, if possible.

The health care provider will measure and monitor the person's vital signs, including temperature, pulse, breathing rate, and blood pressure. Symptoms will be treated as appropriate. The person may receive:

• Activated charcoal
• Airway support, including oxygen, breathing tube through the mouth (intubation), and ventilator (breathing machine)
• Blood and urine tests
• Chest x-ray
• ECG (electrocardiogram, or heart tracing)
• Fluids through the vein (intravenous or IV)
• Laxative
• Medicines to treat symptoms

Survival past 24 hours is usually a good sign that the person will recover. Some individuals may have long-lasting complications if multiple organs are damaged by the drug.

Products containing tetrahydrozoline can interact with many prescription drugs. Always read the label before using any over-the-counter (OTC) product.

In young children, serious adverse events can occur from ingesting only a small amount (1 to 2 mL, or several drops) of tetrahydrozoline. Many of these types of OTC products do not have child-resistant closures, so they should be stored out of the reach of children.

Tetryzoline; Murine; Visine

Aronson JK. Tetryzoline. In: Aronson JK, ed. Meyler's Side Effects of Drugs. 16th ed. Waltham, MA: Elsevier; 2016:793.

Updated by: Jesse Borke, MD, CPE, FAAEM, FACEP, Attending Physician at Kaiser Permanente, Orange County, CA. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.