Indomethacin can be harmful in large amounts.

Indocin is the name of the medicine that contains indomethacin.

Below are symptoms of an indomethacin overdose in different parts of the body.

EYES, EARS, NOSE, AND THROAT

• Blurred vision
• Ringing in the ears

BLADDER AND KIDNEYS

• Little or no urine output

HEART AND BLOOD

• Chest pain
• High or low blood pressure
• Increased heart rate
• Edema (swelling in the body or legs)

STOMACH AND INTESTINES

• Diarrhea
• Nausea (common)
• Possible bleeding in the stomach and intestines
• Stomach pain
• Vomiting (common, sometimes with blood)

LUNGS AND AIRWAYS

• Difficulty breathing
• Wheezing

NERVOUS SYSTEM

• Headache
• Agitation
• Coma (decreased level of consciousness and lack of responsiveness) in severe overdoses
• Confusion
• Delirium (person is not making sense)
• Drowsiness
• Fatigue and weakness
• Numbness and tingling
• Seizures in severe overdoses
• Unsteadiness

SKIN

• Blistering rash
• Bruising
• Sweating

Seek medical help right away. Do not make a person throw up unless poison control or a health care provider tells you to do so.

Have this information ready:

• Person's age, weight, and condition
• Name of the product (and strength, if known)
• Time it was swallowed
• Amount swallowed
• If the medicine was prescribed for the person

Your local poison control center can be reached directly by calling the national toll-free Poison Help hotline (1-800-222-1222) from anywhere in the United States. This national hotline will let you talk to experts in poisoning. They will give you further instructions.

This is a free and confidential service. All local poison control centers in the United States use this national number. You should call if you have any questions about poisoning or poison prevention. It does NOT need to be an emergency. You can call for any reason, 24 hours a day, 7 days a week.

Take the container with you to the hospital, if possible.

The provider will measure and monitor the person's vital signs, including temperature, pulse, breathing rate, and blood pressure.

Tests that may be done include:

• Blood and urine tests
• Chest x-ray
• Electrocardiogram (ECG)
• Endoscopy -- camera placed down the throat to check for burns in the esophagus and stomach
  

• Fluids through a vein (by IV)
• Medicine to treat symptoms
  
• Activated charcoal
• Laxative
• Tube through the mouth into the stomach to empty the stomach (gastric lavage)
• Breathing support, including a tube through the mouth into the lungs and connected to a breathing machine (ventilator)

How well someone does depends on how much indomethacin was swallowed and how quickly treatment is received. The faster the medical help is received, the better the chance for recovery.

A mild overdose of this medicine does not usually cause serious problems. There may be some stomach pain and vomiting (possibly with blood).

However, a large amount of internal bleeding is possible, and a blood transfusion may be needed. Endoscopy may be needed to stop the internal bleeding.

In rare cases, there can be ringing in the ears and a bad headache. But these symptoms will likely pass as well.

If kidney damage is severe, dialysis (kidney machine) may be needed until kidney function returns. In some cases, the damage is permanent.

A large overdose can be very harmful to children and adults. Death may occur.

Indocin

Aronson JK. Non-steroidal anti-inflammatory drugs (NSAIDs). In: Aronson JK, ed. Meyler's Side Effects of Drugs. 16th ed. Waltham, MA: Elsevier; 2016:236-272.

Hatten BW. Aspirin and nonsteroidal agents. In: Walls RM, ed. Rosen's Emergency Medicine: Concepts and Clinical Practice. 10th ed. Philadelphia, PA: Elsevier; 2023:chap 139.

Updated by: Jesse Borke, MD, CPE, FAAEM, FACEP, Attending Physician at Kaiser Permanente, Orange County, CA. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.