A blood sample is needed.

The health care provider may tell you to stop taking medicines that can affect the test.

Drugs that can increase GGT level include:

• Acetaminophen
• Alcohol
• Carbamazepine
• Phenytoin
• Phenobarbital

Drugs that can decrease GGT level include:

• Birth control pills
• Clofibrate

When the needle is inserted to draw blood, some people feel moderate pain. Others feel only a prick or stinging. Afterward, there may be some throbbing or a slight bruise. This soon goes away.

GGT is an enzyme found in high levels in the liver, kidney, pancreas, heart, and brain. It is also found in lesser amount in other tissues. An enzyme is a protein that causes a specific chemical change in the body.

This test is used to detect diseases of the liver or bile ducts. It is also done with other tests (such as the ALT, AST, ALP, and bilirubin tests) to tell the difference between liver or bile duct disorders and bone disease.

It may also be done to screen for, or monitor, alcohol use.

The normal range for adults is 5 to 40 U/L.

Normal value ranges may vary slightly among different laboratories. Some labs use different measurements or may test different specimens. Talk to your provider about the meaning of your specific test results.

An increased GGT level may be due to any of the following:

• Alcohol use
• Diabetes
• Flow of bile from the liver is blocked (cholestasis)
• Heart failure
• Lack of blood flow to the liver (liver ischemia)
• Liver tissue death
• Liver cancer or tumor
• Lung disease
• Pancreas disease
• Scarring of the liver (cirrhosis)
• Swollen and inflamed liver (hepatitis)
• Use of drugs that are toxic to the liver

There is little risk involved with having your blood taken. Veins and arteries vary in size from one person to another and from one side of the body to the other. Taking blood from some people may be more difficult than from others.

Other risks associated with having blood drawn are slight but may include:

• Fainting or feeling lightheaded
• Multiple punctures to locate veins
• Hematoma (blood collecting under the skin)
• Excessive bleeding
• Infection (a slight risk any time the skin is broken)

Gamma-GT; GGTP; GGT; Gamma-glutamyl transpeptidase

Daniels L, Khalili M, Goldstein E, Bluth MH, Bowne WB, Pincus MR. Evaluation of liver function. In: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods. 24th ed. Philadelphia, PA: Elsevier; 2022:chap 22.

Pratt DS. Liver chemistry and function tests. In: Feldman M, Friedman LS, Brandt LJ, eds. Sleisenger and Fordtran's Gastrointestinal and Liver Disease: Pathophysiology/Diagnosis/Management. 11th ed. Philadelphia, PA: Elsevier; 2021:chap 73.

Updated by: Jacob Berman, MD, MPH, Clinical Assistant Professor of Medicine, Division of General Internal Medicine, University of Washington School of Medicine, Seattle, WA. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.