Central sleep apnea results when the brain temporarily stops sending signals to the muscles that cause breathing.

The condition often occurs in people who have certain medical problems. For example, it can develop in someone who has a problem with an area of the brain called the brainstem, which controls breathing.

Conditions that can cause or lead to central sleep apnea include:

• Problems that affect the brainstem, including brain infection, stroke, or conditions of the cervical spine (neck)
• Certain medicines, such as narcotic painkillers
• Being at high altitude

If the apnea is not associated with another disease, it is called idiopathic central sleep apnea.

A condition called Cheyne-Stokes respiration can affect people with severe heart failure and can be associated with central sleep apnea. The breathing pattern involves alternating deep and heavy breathing with shallow, or even not breathing, usually while sleeping.

Central sleep apnea is not the same as obstructive sleep apnea. With obstructive sleep apnea, breathing stops and starts because the airway is narrowed or blocked. Central sleep apnea and obstructive sleep apnea can be present in the same person.

People with central sleep apnea have episodes of disrupted breathing during sleep.

Other symptoms may include:

• Chronic fatigue
• Daytime sleepiness
• Morning headaches
• Restless sleep

Other symptoms may occur if the apnea is due to a problem with the nervous system. Symptoms depend on the parts of the nervous system that are affected, and may include:

• Shortness of breath
• Swallowing problems
• Voice changes
• Weakness or numbness throughout the body

Your health care provider will perform a physical exam. Tests will be done to diagnose an underlying medical condition. A sleep study (polysomnography) can confirm sleep apnea.

Other tests that may be done include:

• Echocardiogram
• Lung function testing
• MRI of the brain, spine, or neck
• Blood tests, such as arterial blood gas levels

Treating the condition that is causing central sleep apnea can help manage symptoms. For example, if central sleep apnea is due to heart failure, the goal is to treat the heart failure itself.

Devices used during sleep to aid breathing may be recommended. These include nasal continuous positive airway pressure (CPAP), bilevel positive airway pressure (BiPAP) or adaptive servo-ventilation (ASV). Some types of central sleep apnea are treated with medicines that stimulate breathing.

Oxygen treatment may help ensure the lungs get enough oxygen while sleeping.

If narcotic medicine is causing the apnea, the dosage may need to be lowered or the medicine changed.

The FDA has approved a medical device (remede System) to treat central sleep apnea. The device is implanted in the chest. When a breathing pause is detected, the device stimulates the nerve that controls the breathing muscles so that you will breathe.

How well you do depends on the medical condition causing central sleep apnea.

The outlook is usually favorable for people with idiopathic central sleep apnea.

Complications may result from the underlying disease causing the central sleep apnea.

Contact your provider if you have symptoms of sleep apnea. Central sleep apnea is usually diagnosed in people who are already severely ill.

Sleep apnea - central; Obesity - central sleep apnea; Cheyne-Stokes - central sleep apnea; Heart failure - central sleep apnea

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Ryan CM, Bradley TD. Central sleep apnea. In: Broaddus VC, Ernst JD, King TE, et al, eds. Murray and Nadel's Textbook of Respiratory Medicine. 7th ed. Philadelphia, PA: Elsevier; 2022:chap 121.

Zinchuk AV, Thomas RJ. Central sleep apnea: diagnosis and management. In: Kryger M, Roth T, Goldstein CA, Dement WC, eds. Principles and Practice of Sleep Medicine. 7th ed. Philadelphia, PA: Elsevier; 2022:chap 125.

Updated by: Allen J. Blaivas, DO, Division of Pulmonary, Critical Care, and Sleep Medicine, VA New Jersey Health Care System, Clinical Assistant Professor, Rutgers New Jersey Medical School, East Orange, NJ. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.