• If you have not used the inhaler in a while, you may need to prime it. See the instructions that came with your inhaler for when and how to do this.
• Take the cap off.
• Look inside the mouthpiece and make sure there is nothing in it.
• Shake the inhaler hard 10 to 15 times before each use.
• Breathe out all the way. Try to push out as much air as you can.

• Hold the inhaler with the mouthpiece down. Place your lips around the mouthpiece so that you form a tight seal.
• As you start to slowly breathe in through your mouth, press down on the inhaler one time.
• Keep breathing in slowly, as deeply as you can.

• Take the inhaler out of your mouth. If you can, hold your breath as you slowly count to 10. This lets the medicine reach deep into your lungs.
• Pucker your lips and breathe out slowly through your mouth.
• If you are using inhaled, quick-relief medicine (beta-agonists), wait 1 to 2 minutes before you take your next puff. You do not need to wait between puffs for other medicines.
• Put the cap back on the mouthpiece and make sure it is firmly closed.
• After using your inhaler, rinse your mouth with water, gargle, and spit. Do not swallow the water. This helps reduce side effects from your medicine.

Look at the hole where the medicine sprays out of your inhaler. If you see powder in or around the hole, clean your inhaler.

• Remove the metal canister from the L-shaped plastic mouthpiece.
• Rinse only the mouthpiece and cap in warm water.
• Let them air-dry overnight.
• In the morning, put the canister back inside. Put the cap on.
• Do not rinse any other parts.

Many inhalers come with counters on the canister. Keep an eye on the counter and replace the inhaler before you run out of medicine.

Do not put your canister in water to see if it is empty. This does not work.

Bring your inhaler to your clinic appointments. Your health care provider can make sure you are using it the right way.

Store your inhaler at room temperature. It may not work well if it is too cold. The medicine in the canister is under pressure. So make sure you do not get it too hot or puncture it.

Metered-dose inhaler (MDI) administration - no spacer; Bronchial nebulizer; Wheezing - nebulizer; Reactive airway - nebulizer; COPD - nebulizer; Chronic bronchitis - nebulizer; Emphysema - nebulizer

Laube BL, Dolovich MB. Aerosols and aerosol drug delivery systems. In: Burks AW, Holgate ST, O'Hehir RE, et al, eds. Middleton's Allergy Principles and Practice. 9th ed. Philadelphia, PA: Elsevier; 2020:chap 63.

Waller DG. Asthma and chronic obstructive pulmonary disease. In: Waller DG, ed. Medical Pharmacology and Therapeutics. 6th ed. Philadelphia, PA: Elsevier; 2022:chap 12.

Updated by: Frank D. Brodkey, MD, FCCM, Associate Professor, Section of Pulmonary and Critical Care Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.