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Antacids help to treat heartburn (indigestion). They work by neutralizing the stomach acid that causes heartburn.
You can buy many antacids without a prescription. Liquid forms work faster, but you may prefer tablets because they are easy to use.
All antacids work equally well, but they can cause different side effects. If you use antacids often and have problems with side effects, talk with your health care provider.
When to Use Antacids
Antacids are a good treatment for heartburn that occurs once in a while. Take antacids about 1 hour after eating or when you have heartburn. If you are taking them for symptoms at night, do not take them with food.
Antacids cannot treat more serious problems, such as appendicitis, a stomach ulcer, gallstones, or bowel problems. Talk to your provider if you have:
- Pain or symptoms that do not get better with antacids
- Symptoms every day or at night
- Nausea and vomiting
- Bleeding in your bowel movements or darkened bowel movements
- Bloating or cramping
- Pain in your lower belly, on your side, or in your back
- Diarrhea that is severe or does not go away
- Fever with your belly pain
- Chest pain or shortness of breath
- Trouble swallowing
- Weight loss that you cannot explain
Contact your provider if you need to use antacids on most days.
Side Effects of Antacids
You may have side effects from taking these medicines. Antacids are made with 3 basic ingredients. If you have problems, try another brand.
- Brands with magnesium may cause diarrhea.
- Brands with calcium or aluminum may cause constipation.
- Rarely, brands with calcium may cause kidney stones or other problems.
- If you take large amounts of antacids that contain aluminum, you may be at risk for calcium loss, which can lead to weak bones (osteoporosis).
Antacids can change the way your body absorbs the other medicines you are taking. It is best to take any other medicine either 1 hour before or 24 hours after you take antacids.
Talk to your provider or pharmacist before taking antacids on a regular basis if:
- You have kidney disease, high blood pressure, or heart disease.
- You are on a low-sodium diet.
- You are already taking calcium.
- You are taking other medicines every day.
- You have had kidney stones.
Alternative Names
Heartburn - antacids; Reflux - antacids; GERD - antacids
References
Abdul-Hussein M. Gastroesophageal reflux disease (GERD). In: Kellerman RD, Rakel DP, Heidelbaugh JJ, Lee EM, eds. Conn's Current Therapy 2024. Philadelphia, PA: Elsevier; 2024:230-233.
Falk GW, Katzka DA. Diseases of the esophagus. In: Goldman L, Cooney KA, eds. Goldman-Cecil Medicine. 26th ed. Philadelphia, PA: Elsevier; 2020:chap 124.
Katz PO, Dunbar KB, Schnoll-Sussman FH, Greer KB, Yadlapati R, Spechler SJ. ACG clinical guideline for the diagnosis and management of gastroesophageal reflux disease. Am J Gastroenterol. 2022;117(1):27-56. PMID: 34807007pubmed.ncbi.nlm.nih.gov/34807007/.
Kopf PG, Prozialeck W. Gastrointestinal disorders and their treatment. In: Wecker L, Ingram SL, eds. Brody's Human Pharmacology. 7th ed. Philadelphia, PA: Elsevier; 2025:chap 72.
Richter JE,Vaezi MF. Gastroesophageal reflux disease. In: Feldman M, Friedman LS, Brandt LJ, eds. Sleisenger and Fordtran's Gastrointestinal and Liver Disease. 11th ed. Philadelphia, PA: Elsevier; 2021:chap 46.
Patient Instructions
Review Date 10/30/2024
Updated by: Jenifer K. Lehrer, MD, Gastroenterologist, Philadelphia, PA. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.