Health Topics
Official websites use .gov
A
.gov website belongs to an official government
organization in the United States.
Secure .gov websites use HTTPS
A
lock (
) or https:// means you’ve safely connected to
the .gov website. Share sensitive information only on official,
secure websites.
Normal Function
The NTN1 gene provides instructions for making a protein called netrin-1, which is involved in the development of the nervous system. This protein attaches (binds) to a protein called netrin-1 receptor, and these two proteins fit together like a lock and key. The binding of netrin-1 to its receptor helps direct the growth of specialized nerve cell extensions called axons. Axons transmit nerve impulses that can signal muscle movement.
When the brain sends a signal to trigger muscle movement, the signal usually travels from one half of the brain to the opposite side of the body. Binding netrin-1 to its receptor allows axons to develop this signaling pathway.
Health Conditions Related to Genetic Changes
Congenital mirror movement disorder
NTN1 gene variants (also called mutations) have been identified in people with congenital mirror movement disorder, a condition in which intentional movements of one side of the body are mirrored by involuntary movements of the other side of the body. These variants change single protein building blocks (amino acids) in the netrin-1 protein or cause cells to produce an abnormally short version of the protein. Without functional netrin-1 proteins, the growth of axons during nervous system development is not properly directed. As a result, movement signals that originate in one half of the brain are transmitted to both sides of the body, leading to mirror movements.
More About This Health ConditionOther Names for This Gene
- MRMV4
- NET1
- NTN1L
Additional Information & Resources
Tests Listed in the Genetic Testing Registry
Scientific Articles on PubMed
Catalog of Genes and Diseases from OMIM
References
- Boyer NP, Gupton SL. Revisiting Netrin-1: One Who Guides (Axons). Front Cell Neurosci. 2018 Jul 31;12:221. doi: 10.3389/fncel.2018.00221. eCollection 2018. Citation on PubMed
- Dun XP, Parkinson DB. Role of Netrin-1 Signaling in Nerve Regeneration. Int J Mol Sci. 2017 Feb 24;18(3):491. doi: 10.3390/ijms18030491. Citation on PubMed
- Meneret A, Franz EA, Trouillard O, Oliver TC, Zagar Y, Robertson SP, Welniarz Q, Gardner RJM, Gallea C, Srour M, Depienne C, Jasoni CL, Dubacq C, Riant F, Lamy JC, Morel MP, Guerois R, Andreani J, Fouquet C, Doulazmi M, Vidailhet M, Rouleau GA, Brice A, Chedotal A, Dusart I, Roze E, Markie D. Mutations in the netrin-1 gene cause congenital mirror movements. J Clin Invest. 2017 Nov 1;127(11):3923-3936. doi: 10.1172/JCI95442. Epub 2017 Sep 25. Citation on PubMed
The information on this site should not be used as a substitute for professional medical care or advice. Contact a health care provider if you have questions about your health.