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Hormone Replacement Therapy
URL of this page: https://medlineplus.gov/hormonereplacementtherapy.html

Hormone Replacement Therapy

Also called: ERT, Estrogen replacement therapy, HRT, Menopausal hormone therapy
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Summary

Menopause is the time in a woman's life when her period stops. It is a normal part of aging. In the years before and during menopause, the levels of female hormones can go up and down. This can cause symptoms such as hot flashes, night sweats, pain during sex, and vaginal dryness. For some women, the symptoms are mild, and they go away on their own. Other women take hormone replacement therapy (HRT), also called menopausal hormone therapy, to relieve these symptoms. HRT may also protect against osteoporosis.

HRT is not for everyone. You should not use HRT if you:

  • Think that you are pregnant
  • Have problems with vaginal bleeding
  • Have had certain kinds of cancers
  • Have had a stroke or heart attack
  • Have had blood clots
  • Have liver disease

There are different types of HRT. Some have only one hormone, while others have two. Most are pills that you take every day, but there are also skin patches, vaginal creams, gels, and rings.

Taking HRT has some risks. For some women, hormone therapy may increase their chances of getting blood clots, heart attacks, strokes, breast cancer, and gallbladder disease. Certain types of HRT have a higher risk, and each woman's own risks can vary, depending upon her medical history and lifestyle. You and your health care provider need to discuss the risks and benefits for you. If you do decide to take HRT, it should be the lowest dose that helps and for the shortest time needed. You should check if you still need to take HRT every 3-6 months.

Food and Drug Administration

Start Here

  • Menopause and Hormones: Common Questions (Food and Drug Administration) - PDF Also in Spanish
  • Menopause: Medicines to Help You (Food and Drug Administration)

Treatments and Therapies

  • 4 Things to Know about Menopausal Symptoms and Complementary Health Practices From the National Institutes of Health (National Center for Complementary and Integrative Health)

Related Issues

  • Menopausal Hormone Therapy and Cancer From the National Institutes of Health (National Cancer Institute) Also in Spanish
  • Menopause Hormone Therapy: Does It Cause Vaginal Bleeding? (Mayo Foundation for Medical Education and Research) Also in Spanish
  • Menopause Treatment (Department of Health and Human Services, Office on Women's Health)

Clinical Trials

  • ClinicalTrials.gov: Estrogen Replacement Therapy From the National Institutes of Health (National Institutes of Health)
  • ClinicalTrials.gov: Hormone Replacement Therapy From the National Institutes of Health (National Institutes of Health)

Journal Articles References and abstracts from MEDLINE/PubMed (National Library of Medicine)

  • Article: Association between menopause, postmenopausal hormone therapy and peptic ulcer disease in...
  • Article: Treatment of hypothyroidism with levothyroxine plus slow-release liothyronine: a study protocol...
  • Article: Effects of gender affirming hormone therapy with testosterone on renal function...
  • Hormone Replacement Therapy -- see more articles

Find an Expert

  • Department of Health and Human Services, Office on Women's Health Also in Spanish
  • Endocrine Society
  • National Institute on Aging From the National Institutes of Health Also in Spanish

Patient Handouts

  • Deciding about hormone therapy (Medical Encyclopedia) Also in Spanish
  • Types of hormone therapy (Medical Encyclopedia) Also in Spanish

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Hormone Replacement Therapy

MEDICAL ENCYCLOPEDIA

  • Deciding about hormone therapy
  • Estrogen overdose
  • Types of hormone therapy

Related Health Topics

  • Menopause

National Institutes of Health

The primary NIH organization for research on Hormone Replacement Therapy is the National Institute on Aging

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The information on this site should not be used as a substitute for professional medical care or advice. Contact a health care provider if you have questions about your health.

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