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Pemphigus
URL of this page: https://medlineplus.gov/pemphigus.html

Pemphigus

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Summary

Pemphigus is an autoimmune disorder. If you have it, your immune system attacks healthy cells in your skin and mouth, causing blisters and sores. No one knows the cause. Pemphigus does not spread from person to person. It does not appear to be inherited. But some people's genes put them more at risk for pemphigus.

Pemphigoid is also an autoimmune skin disease. It leads to deep blisters that do not break easily. Pemphigoid is most common in older adults and may be fatal for older, sick patients.

Doctors diagnose pemphigus with a physical exam, a biopsy, and blood tests. The treatment of pemphigus and pemphigoid is the same: one or more medicines to control symptoms. These may include:

  • Steroids, which reduce inflammation
  • Drugs that suppress the immune system response
  • Antibiotics to treat associated infections

NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases

Start Here

  • Pemphigus From the National Institutes of Health (National Institute of Arthritis and Musculoskeletal and Skin Diseases) Also in Spanish

Specifics

  • Bullous Pemphigoid (American Osteopathic College of Dermatology)
  • Hailey-Hailey Disease (Benign Chronic Pemphigus) (American Osteopathic College of Dermatology)
  • Mucous Membrane Pemphigoid From the National Institutes of Health (Genetic and Rare Diseases Information Center)

Images

  • Pemphigus Vulgaris (VisualDX)

Clinical Trials

  • ClinicalTrials.gov: Pemphigoid, Benign Mucous Membrane From the National Institutes of Health (National Institutes of Health)
  • ClinicalTrials.gov: Pemphigoid, Bullous From the National Institutes of Health (National Institutes of Health)
  • ClinicalTrials.gov: Pemphigus From the National Institutes of Health (National Institutes of Health)

Journal Articles References and abstracts from MEDLINE/PubMed (National Library of Medicine)

  • Article: Recent advances in the genetics and innate immune cells of bullous...
  • Article: Treatment of pemphigus and other neglected skin conditions with PC111, a human...
  • Article: Correlation and assessment of vitamin D deficiency with disease severity in...
  • Pemphigus -- see more articles

Find an Expert

  • Find a Dermatologist (American Academy of Dermatology)
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases From the National Institutes of Health Also in Spanish

Patient Handouts

  • Bullous pemphigoid (Medical Encyclopedia) Also in Spanish
  • Pemphigus vulgaris (Medical Encyclopedia) Also in Spanish

Topic Image

Pemphigus

MEDICAL ENCYCLOPEDIA

  • Bullous pemphigoid
  • Nikolsky sign
  • Pemphigus vulgaris

National Institutes of Health

The primary NIH organization for research on Pemphigus is the National Institute of Arthritis and Musculoskeletal and Skin Diseases

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The information on this site should not be used as a substitute for professional medical care or advice. Contact a health care provider if you have questions about your health.

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