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Blisters
URL of this page: https://medlineplus.gov/blisters.html

Blisters

Also called: Bulla, Vesicle

Summary

What are blisters?

Blisters are fluid-filled sacs on the outer layer of your skin. They form because of rubbing, heat, or diseases of the skin. They are most common on your hands and feet.

Other names for blisters are vesicles (usually for smaller blisters) and bulla (for larger blisters).

What causes blisters?

Blisters often happen when there is friction - rubbing or pressure - on one spot. For example, if your shoes don't fit quite right and they keep rubbing part of your foot. Or if you don't wear gloves when you rake leaves and the handle keeps rubbing against your hand. Other causes of blisters include:

  • Burns
  • Sunburn
  • Frostbite
  • Eczema
  • Allergic reactions
  • Poison ivy, oak, and sumac
  • Autoimmune diseases such as pemphigus
  • Epidermolysis bullosa, an illness that causes the skin to be fragile
  • Viral infections such as varicella zoster (which causes chickenpox and shingles) and herpes simplex (which causes cold sores)
  • Skin infections including impetigo

What are the treatments for blisters?

Blisters will usually heal on their own. The skin over the blister helps keep out infections. You can put a bandage on the blister to keep it clean. Make sure that there is no more rubbing or friction on the blister.

You should contact your health care provider if:

  • The blister looks infected - if it is draining pus, or the area around the blister is red, swollen, warm, or very painful
  • You have a fever
  • You have several blisters, especially if you cannot figure out what is causing them
  • You have health problems such as circulation problems or diabetes

Normally you don't want to drain a blister, because of the risk of infection. But if a blister is large, painful, or looks like it will pop on its own, you can drain the fluid.

Can blisters be prevented?

There are some things you can do to prevent friction blisters:

  • Make sure that your shoes fit properly
  • Always wear socks with your shoes, and make sure that the socks fit well. You may want to wear socks that are acrylic or nylon, so they keep moisture away from your feet.
  • Wear gloves or protective gear on your hands when you use any tools or sports equipment that cause friction.

Learn More

  • Blisters, Calluses, and Corns (Nemours Foundation) Also in Spanish
  • Blisters, First Aid (VisualDX)
  • Blisters: First Aid (Mayo Foundation for Medical Education and Research) Also in Spanish
  • How To Prevent and Treat Blisters (American Academy of Dermatology)
  • Vesicles (Medical Encyclopedia) Also in Spanish

Clinical Trials

  • ClinicalTrials.gov: Blister From the National Institutes of Health (National Institutes of Health)

Journal Articles References and abstracts from MEDLINE/PubMed (National Library of Medicine)

  • Article: Bleb resuscitation of failing, leaking and dysfunctional blebs: A review.
  • Article: The translational potential of inflammation-induced skin blister human models in exploring...
  • Article: Integrin mutations in blistering skin diseases and related genetically engineered mouse...
  • Blisters -- see more articles

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Blisters

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The information on this site should not be used as a substitute for professional medical care or advice. Contact a health care provider if you have questions about your health.

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Last updated March 17, 2025
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