Staphylococcal meningitis is caused by staphylococcus bacteria. When it is caused by Staphylococcus aureus or Staphylococcus epidermidis bacteria, it usually develops as a complication of surgery or as an infection that spreads through the blood from another site.

Risk factors include:

• Infections of heart valves
• Past infection of the brain
• Past meningitis due to spinal fluid shunts
• Recent brain surgery
• The presence of a spinal fluid shunt
• Trauma
• Bloodstream infection with Staphylococcus aureus

Symptoms may come on quickly, and include:

• Fever and chills
• Mental status changes
• Nausea and vomiting
• Sensitivity to light (photophobia)
• Severe headache
• Stiff neck

Other symptoms that can occur with this disease:

• Agitation
• Bulging fontanelles in infants
• Decreased alertness
• Poor feeding or irritability in children
• Rapid breathing
• Unusual posture, with the head and neck arched backwards (opisthotonos)

The health care provider will perform a physical exam. Questions will focus on symptoms and risk factors.

If the doctor thinks meningitis is possible, a lumbar puncture (spinal tap) is done to remove a sample of spinal fluid for testing. If you have a spinal fluid shunt, the sample may be taken from this instead.

Tests may include:

• Blood culture
• Chest x-ray
• CT scan of the head
• Gram stain or other special stains, and culture of the spinal fluid

Antibiotics will be started as soon as possible. Vancomycin is the first choice for suspected staphylococcal meningitis. Nafcillin is used when tests show that the bacteria are sensitive to this antibiotic.

Often, treatment will include a search for, and removal of, possible sources of bacteria in the body. These include shunts or artificial heart valves.

Early treatment improves the outcome. However, some people do not survive. Young children and adults over age 50 have the highest risk for death.

Staphylococcal meningitis often improves more quickly, with fewer complications, if the source of the infection is removed. The source may include shunts, hardware in joints, or artificial heart valves.

Long-term complications may include:

• Brain damage
• Buildup of fluid between the skull and brain (subdural effusion)
• Buildup of fluid inside the skull that leads to brain swelling (hydrocephalus)
• Hearing loss
• Seizures
• Staph infection in another area of the body

Call 911 or the local emergency number or go to an emergency room if you suspect meningitis in a young child who has the following symptoms:

• Feeding problems
• High-pitched cry
• Irritability
• Persistent, unexplained fever

Meningitis can quickly become a life-threatening illness.

In high-risk people, taking antibiotics before diagnostic or surgical procedures may help reduce the risk. Discuss this with your doctor.

Centers for Disease Control and Prevention website. Meningitis. About bacterial meningitis. www.cdc.gov/meningitis/about/bacterial-meningitis.html. Updated January 9, 2024. Accessed June 17, 2024.

Nath A. Meningitis: bacterial, viral, and other. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 26th ed. Philadelphia, PA: Elsevier; 2020:chap 384.

Hasbun R, Van de Beek D, Brouwer MC, Tunkel AR. Acute meningitis. In: Bennett JE, Dolin R, Blaser MJ, eds. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 9th ed. Philadelphia, PA: Elsevier; 2020:chap 87.

Updated by: Jatin M. Vyas, MD, PhD, Associate Professor in Medicine, Harvard Medical School; Associate in Medicine, Division of Infectious Disease, Department of Medicine, Massachusetts General Hospital, Boston, MA. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.