In 35% to 67% of cases, SRS is due to a variant in chromosome 11. A variant in chromosome 7 accounts for 7% to 10% of cases. The remaining 30% to 40% of cases have unknown causes.

Most of the time, it occurs in people with no family history of the disease.

The estimated number of people who develop this condition varies greatly. Males and females are equally affected.

Symptoms can include:

• Birthmarks that are the color of coffee with milk (cafe-au-lait marks)
• Large head for body size, wide projecting forehead with a small triangle-shaped face and small, narrow chin
• Curving of the pinky toward the ring finger
• Failure to thrive, including delayed bone age
• Low birth weight
• Short height, short arms, stubby fingers and toes
• All or part of one side of the body is smaller than the other side (asymmetry)
• Stomach and intestine problems such as acid reflux and constipation

The condition is usually diagnosed by early childhood. Your health care provider will perform a physical exam.

There are no specific lab tests to diagnose SRS. The diagnosis is usually based on the judgment of your child's provider. However, the following tests may be done:

• Blood sugar (some children may have low blood sugar)
• Bone age testing (bone age is often younger than the child's actual age)
• Genetic testing (may detect a chromosomal problem)
• Growth hormone (some children may have a deficiency)
• Skeletal survey (to check for other conditions that may mimic SRS)

Growth hormone replacement may help if this hormone is lacking. Other treatments include:

• Making sure the person gets enough calories to prevent low blood sugar and promote growth
• Physical therapy to improve muscle tone
• Educational assistance to address learning disabilities and attention deficit problems the child may have

Many specialists may be involved in treating a person with this condition. They include:

• A doctor specializing in genetics to help diagnose SRS
• A gastroenterologist or dietician to help develop the proper diet to enhance growth
• An endocrinologist to prescribe growth hormone
• A genetic counselor and psychologist

Older children and adults do not show typical features as clearly as infants or younger children. Intelligence may be normal, although the person may have a learning disability. Birth defects of the urinary tract may be present.

People with SRS may have these problems:

• Chewing or speaking difficulty if jaw is very small
• Learning disabilities

Contact your child's provider if signs of SRS develop. Make sure your child's height and weight are measured during each well-child visit. Your provider may refer you to:

• A genetic professional for a full evaluation and chromosome studies
• A pediatric endocrinologist for management of your child's growth problems

Russell-Silver syndrome; Silver syndrome; SRS

Senaratne TN, Zackai EH, Saitta SC. Chromosome disorders. In: Gleason CA, Sawyer T, eds. Avery's Diseases of the Newborn. 11th ed. Philadelphia, PA: Elsevier; 2024:chap 28.

Wakeling EL, Brioude F, Lokulo-Sodipe O, et al. Diagnosis and management of Silver-Russell syndrome: first international consensus statement. Nat Rev Endocrinol. 2017;13(2):105-124. PMID: 27585961 pubmed.ncbi.nlm.nih.gov/27585961/.

Updated by: Anna C. Edens Hurst, MD, MS, Associate Professor in Medical Genetics, The University of Alabama at Birmingham, Birmingham, AL. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team. Editorial update 03/05/2025.