The health care provider will inject a radioactive material called a radioisotope into one of your veins. After the liver has soaked up the material, you will be asked to lie on a table under the scanner.

The scanner can tell where the radioactive material has gathered in the body. Images are displayed on a computer. You may be asked to remain still, or to change positions during the scan.

You will be asked to sign a consent form. You will be asked to remove jewelry, dentures, and other metals that can affect the scanner's functions.

You may need to wear a hospital gown.

You will feel a sharp prick when the needle is inserted into your vein. You should not feel anything during the actual scan. If you have problems lying still or are very anxious, you may be given a mild medicine (sedative) to help you relax.

The test can provide information about liver and spleen function. It is also used to help confirm other test results.

The most common use for a liver scan is to diagnose a condition called benign focal nodular hyperplasia, or FNH, which causes a non-cancerous mass in the liver.

The liver and spleen should look normal in size, shape, and location. The radioisotope is absorbed evenly.

Abnormal results may indicate:

• Focal nodular hyperplasia or adenoma of the liver
• Abscess
• Budd-Chiari syndrome
• Infection
• Liver disease (such as cirrhosis or hepatitis)
• Superior vena cava obstruction
• Splenic infarction (tissue death)
• Tumors

Radiation from any scan is always a slight concern. The level of radiation in this procedure is less than that of most x-rays. It is not considered to be enough to cause harm to the average person.

Pregnant or nursing women should consult their provider before any exposure to radiation.

Other tests may be needed to confirm the findings of this test. These may include:

• Abdominal ultrasound
• Abdominal CT scan
• Abdominal MRI scan
• Liver biopsy

This test is used infrequently. Instead, MRI or CT scans are more often used to evaluate the liver and spleen.

Technetium scan; Liver technetium sulfur colloid scan; Liver-spleen radionuclide scan; Nuclear scan - technetium; Nuclear scan - liver or spleen

Mettler FA, Guiberteau MJ. Gastrointestinal tract. In: Mettler FA, Guiberteau MJ, eds. Essentials of Nuclear Medicine and Molecular Imaging. 7th ed. Philadelphia, PA: Elsevier; 2019:chap 7.

Squires JH, Narayanan S, Tadros S. Fundamentals of pediatric radiology. In: Zitelli BJ, McIntire SC, Nowalk AJ, Garrison J, eds. Zitelli and Davis' Atlas of Pediatric Physical Diagnosis. 8th ed. Philadelphia, PA: Elsevier; 2023:chap 25.

Tirkes T, Sandrasegaran K. Investigative imaging of the liver. In: Saxena R, ed. Practical Hepatic Pathology: A Diagnostic Approach. 2nd ed. Philadelphia, PA: Elsevier; 2018:chap 4.

Updated by: Jason Levy, MD, FSIR, Northside Radiology Associates, Atlanta, GA. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.