An enteroscope uses a long flexible tube with a balloon and a camera attached that can go deep down the inside of the small bowel.

During a single- or double-balloon enteroscopy, balloons attached to the endoscope can be inflated to allow the doctor to view a section of the small intestine. The enteroscope is usually inserted through the mouth for upper enteroscopy.

In a colonoscopy, a flexible tube is inserted through your rectum and colon. The tube can most often reach into the end part of the small intestine (ileum). Occasionally, an enteroscope is inserted through the rectum to reach further into the end of the small intestine.

Capsule endoscopy is done with a disposable capsule that you swallow. This transmits pictures to a recorder and is uploaded to a computer for viewing the pictures.

Tissue samples removed during enteroscopy are sent to the lab for examination. (Biopsies cannot be taken with a capsule endoscopy.)

Tell the doctor doing your enteroscopy if you take blood thinners such as warfarin (Coumadin), clopidogrel (Plavix), apixaban (Eliquis), aspirin, or daily NSAIDs because these may interfere with the test. Do not stop taking any medicine unless told to do so by your doctor or health care provider.

Do not eat any solid foods or milk products after midnight on the day of your procedure. You may have clear liquids until 4 hours before your exam. Occasionally a laxative is given before the enteroscopy. Follow your specific instructions.

You must sign a consent form.

You will be given calming and sedating medicine for the procedure and will not feel any discomfort. You may have some bloating or cramping when you wake up. This is from air that is pumped into the abdomen to expand the area during the procedure.

A capsule endoscopy causes no discomfort.

This test is most often performed to help diagnose diseases of the small intestine. It may be done if you have:

• Abnormal x-ray results
• Tumors in the small intestine
• Unexplained diarrhea
• Unexplained gastrointestinal bleeding

In a normal test result, the doctor will not find sources of bleeding in the small bowel, and will not find any tumors or other abnormal tissue.

Abnormal signs during an enteroscopy may include:

• Abnormalities of the tissue lining the small intestine (mucosa) or the tiny, finger-like projections on the surface of the small intestine (villi)
• Abnormal lengthening of blood vessels (angioectasia) in the intestinal lining
• Immune cells called PAS-positive macrophages
• Polyps or cancer
• Radiation enteritis
• Swollen or enlarged lymph nodes or lymphatic vessels
• Ulcers

Changes found on enteroscopy may be signs of disorders and conditions, including:

• Amyloidosis
• Celiac disease
• Crohn disease
• Folate or vitamin B12 deficiency
• Giardiasis
• Infectious gastroenteritis
• Lymphangiectasia
• Lymphoma
• Small intestinal angioectasia
• Small intestinal cancer
  
• Tropical sprue
• Whipple disease

Complications are rare but may include:

• Excessive bleeding from the biopsy site
• Hole in the bowel (bowel perforation)
• Infection of the biopsy site leading to bacteremia (bacteria in the bloodstream)
• Vomiting, followed by aspiration into the lungs
• The capsule endoscope can cause a blockage in a narrowed intestine with symptoms of abdominal pain and bloating
  
  

Factors that prohibit use of this test may include:

• Uncooperative or confused person
• Untreated blood clotting (coagulation) disorders
• Use of medicines that prevent the blood from clotting normally (anticoagulants)

The greatest risk is bleeding. Signs of bleeding include:

• Abdominal pain
• Blood in the stools
• Vomiting blood

Push enteroscopy; Double-balloon enteroscopy; Single-balloon enteroscopy; Spiral enteroscopy; Capsule enteroscopy

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Rojas I, Barth B. Capsule endoscopy and small bowel enteroscopy. In: Wyllie R, Hyams JS, Kay M, eds. Pediatric Gastrointestinal and Liver Disease. 6th ed. Philadelphia, PA: Elsevier; 2021:chap 63.

Sugumar A, Vargo JJ. Preparation for and complications of gastrointestinal endoscopy. In: Feldman M, Friedman LS, Brandt LJ, eds. Sleisenger and Fordtran's Gastrointestinal and Liver Disease. 11th ed. Philadelphia, PA: Elsevier; 2021:chap 42.

Waterman M, Zurad EG, Gralnek IM. Video capsule endoscopy. In: Fowler GC, ed. Pfenninger and Fowler's Procedures for Primary Care. 4th ed. Philadelphia, PA: Elsevier; 2020:chap 93.

Updated by: Jenifer K. Lehrer, MD, Department of Gastroenterology, Aria - Jefferson Health Torresdale, Jefferson Digestive Diseases Network, Philadelphia, PA. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.