SIGN IN YOUR ACCOUNT TO HAVE ACCESS TO DIFFERENT FEATURES

FORGOT YOUR PASSWORD?

FORGOT YOUR DETAILS?

AAH, WAIT, I REMEMBER NOW!
24/7 HELPLINE (903) 212-7500
  • PATIENT PORTAL LOGIN

PhyNet Health PhyNet Health

  • Home
  • Find a Clinic
    • Hughes Springs, TX
    • Longview, TX
    • Jefferson, TX
    • Kilgore, TX
    • Lindale, TX
    • Linden, TX
    • Gladewater, TX
    • Lone Star, TX
    • Tatum, TX
    • Marshall, TX
  • Health Services
    • Primary Care Services
    • Physical Therapy / Rehab
    • Allergy Testing & Treatment
    • Chronic Care Management
    • Remote Monitoring Program
    • Virtual Visit
  • Resources
    • MedlinePlus Wiki
      • Health Topics
    • Home Health Coordination
    • Transitions of Care
    • Insurance Help
  • About Phynet
    • About Phynet
    • PhyNet News
    • Better Together Stories
    • Careers
  • Billing

Health Topics

Skip navigation

An official website of the United States government

Here’s how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( Lock Locked padlock icon ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

National Institutes of Health National Library of Medicine
MedlinePlus Trusted Health Information for You
  • Health Topics
  • Drugs & Supplements
  • Genetics
  • Medical Tests
  • Medical Encyclopedia
  • About MedlinePlus
  • About MedlinePlus
  • What's New
  • Site Map
  • Customer Support
  • Health Topics
  • Drugs & Supplements
  • Genetics
  • Medical Tests
  • Medical Encyclopedia
You Are Here:
Home →
Genetics →
Genes →
FOXP2 gene
URL of this page: https://medlineplus.gov/genetics/gene/foxp2/

FOXP2 gene

forkhead box P2

Normal Function

The FOXP2 gene provides instructions for making a protein that acts as a transcription factor, which means that it controls the activity of other genes. It attaches (binds) to the DNA of these genes at a region of the protein known as a forkhead domain. Researchers suspect that the FOXP2 protein may regulate the activity of hundreds of genes.

The FOXP2 protein is active in several tissues, including the brain, both before and after birth. Studies suggest that the FOXP2 protein plays a key role in the functioning of synapses, which are the connections between nerve cells (neurons) where cell-to-cell communication occurs. Specifically, this protein is important for synaptic plasticity, which is the ability of synapses to change and adapt to experience over time. Synaptic plasticity is necessary for learning and memory. 

The FOXP2 protein appears to be essential for the normal development of speech and language. Researchers are working to determine which genes are influenced by the FOXP2 protein and how changes in their activity lead to abnormal speech and language development.

Health Conditions Related to Genetic Changes

FOXP2-related speech and language disorder

Several variants (also called mutations) in the FOXP2 gene cause FOXP2-related speech and language disorder, a condition that affects the development of speech and language beginning in early childhood.

The genetic changes that cause FOXP2-related speech and language disorder disrupt the activity of the FOXP2 gene. As a result, cells produce an abnormal version of the FOXP2 protein that does not function properly. Because the FOXP2 protein is a transcription factor, these changes also affect the activity of other genes in the developing brain, many of which are essential for the development of speech and language.

The FOXP2 gene is one of the genes found on chromosome 7. Changes that affect the FOXP2 gene and neighboring genes on this chromosome can cause a disorder known as FOXP2-plus-related speech and language disorder. These changes can include a rearrangement or a deletion of material on chromosome 7. In other cases, an individual inherits two copies of chromosome 7 from the egg cell instead of one copy from the egg cell and one copy from the sperm cell (a phenomenon called uniparental disomy or UPD). Because these changes affect the FOXP2 gene and neighboring genes, people with FOXP2-plus-related speech and language disorder tend to be more severely affected than individuals who only have a variant in the FOXP2 gene.

More About This Health Condition

Other Names for This Gene

  • CAG repeat protein 44
  • CAGH44
  • forkhead/winged-helix transcription factor
  • SPCH1
  • TNRC10
  • trinucleotide repeat containing 10

Additional Information & Resources

Tests Listed in the Genetic Testing Registry

  • Tests of FOXP2 From the National Institutes of Health

Scientific Articles on PubMed

  • PubMed From the National Institutes of Health

Catalog of Genes and Diseases from OMIM

  • FORKHEAD BOX P2; FOXP2

Gene and Variant Databases

  • NCBI Gene From the National Institutes of Health
  • ClinVar From the National Institutes of Health

References

  • Fisher SE, Scharff C. FOXP2 as a molecular window into speech and language. Trends Genet. 2009 Apr;25(4):166-77. doi: 10.1016/j.tig.2009.03.002. Epub 2009 Mar 21. Citation on PubMed
  • Graham SA, Fisher SE. Understanding Language from a Genomic Perspective. Annu Rev Genet. 2015;49:131-60. doi: 10.1146/annurev-genet-120213-092236. Epub 2015 Oct 5. Citation on PubMed
  • Lai CS, Fisher SE, Hurst JA, Vargha-Khadem F, Monaco AP. A forkhead-domain gene is mutated in a severe speech and language disorder. Nature. 2001 Oct 4;413(6855):519-23. doi: 10.1038/35097076. Citation on PubMed
  • MacDermot KD, Bonora E, Sykes N, Coupe AM, Lai CS, Vernes SC, Vargha-Khadem F, McKenzie F, Smith RL, Monaco AP, Fisher SE. Identification of FOXP2 truncation as a novel cause of developmental speech and language deficits. Am J Hum Genet. 2005 Jun;76(6):1074-80. doi: 10.1086/430841. Epub 2005 Apr 22. Citation on PubMed or Free article on PubMed Central
  • Morgan A, Fisher SE, Scheffer I, Hildebrand M. FOXP2-Related Speech and Language Disorder. 2016 Jun 23 [updated 2023 Jan 26]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Amemiya A, editors. GeneReviews(R) [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2025. Available from http://www.ncbi.nlm.nih.gov/books/NBK368474/ Citation on PubMed
  • Nagy O, Karteszi J, Elmont B, Ujfalusi A. Case Report: Expressive Speech Disorder in a Family as a Hallmark of 7q31 Deletion Involving the FOXP2 Gene. Front Pediatr. 2021 Aug 20;9:664548. doi: 10.3389/fped.2021.664548. eCollection 2021. Citation on PubMed
  • Vernes SC, Oliver PL, Spiteri E, Lockstone HE, Puliyadi R, Taylor JM, Ho J, Mombereau C, Brewer A, Lowy E, Nicod J, Groszer M, Baban D, Sahgal N, Cazier JB, Ragoussis J, Davies KE, Geschwind DH, Fisher SE. Foxp2 regulates gene networks implicated in neurite outgrowth in the developing brain. PLoS Genet. 2011 Jul;7(7):e1002145. doi: 10.1371/journal.pgen.1002145. Epub 2011 Jul 7. Citation on PubMed or Free article on PubMed Central
DNA helix

Genomic Location

The FOXP2 gene is found on chromosome 7.

Related Health Topics

  • Genes and Gene Therapy
  • Genetic Disorders

MEDICAL ENCYCLOPEDIA

  • Genes
  • Genetics

Understanding Genetics

  • What is DNA?
  • What is a gene?
  • What is a gene variant and how do variants occur?

Disclaimers

MedlinePlus links to health information from the National Institutes of Health and other federal government agencies. MedlinePlus also links to health information from non-government Web sites. See our disclaimer about external links and our quality guidelines.

The information on this site should not be used as a substitute for professional medical care or advice. Contact a health care provider if you have questions about your health.

  • About MedlinePlus
  • What's New
  • Site Map
  • Customer Support
  • Subscribe to RSSRSS
  • Connect with NLM
  • NLM Web Policies
  • Copyright
  • Accessibility
  • Guidelines for Links
  • Viewers & Players
  • HHS Vulnerability Disclosure
  • MedlinePlus Connect for EHRs
  • For Developers
National Library of Medicine 8600 Rockville Pike, Bethesda, MD 20894 U.S. Department of Health and Human Services National Institutes of Health
Last updated January 21, 2025
Return to top

Patients

  • Find a Clinic
  • Health Services
  • Complex Case Management
  • MA / Medicare Assistance

Quick Links

  • Billing Information
  • Careers
  • About Phynet
  • PhyNet News

Network Links

  • PrimeCareHomeHealth.com
  • PrimeCareNet.com
  • PrimeCareManagers.com
  • Core-Rehab.com

Home Office

4002 Technology Center Longview TX 75605
Phone: (903) 247-0484
Fax: (903) 247-0485
[email protected]
  • PrimeCareHomeHealth.com
  • PrimeCareNet.com
  • PrimeCareManagers.com
  • Core-Rehab.com
  • GET SOCIAL

© 2021 PhyNet Health • All rights reserved
YOUR LIFE. YOUR CHOICE.

TOP