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Bone Marrow Diseases
URL of this page: https://medlineplus.gov/bonemarrowdiseases.html

Bone Marrow Diseases

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Basics

  • Summary
  • Diagnosis and Tests
  • Treatments and Therapies

Learn More

  • Specifics
  • Genetics

See, Play and Learn

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Research

  • Clinical Trials
  • Journal Articles

Resources

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For You

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Summary

Bone marrow is the spongy tissue inside some of your bones, such as your hip and thigh bones. It contains stem cells. The stem cells can develop into the red blood cells that carry oxygen through your body, the white blood cells that fight infections, and the platelets that help with blood clotting.

With bone marrow disease, there are problems with the stem cells or how they develop:

  • In leukemia, a cancer of the blood, the bone marrow makes abnormal white blood cells
  • In aplastic anemia, the bone marrow doesn't make red blood cells
  • In myeloproliferative disorders, the bone marrow makes too many white blood cells
  • Other diseases, such as lymphoma, can spread into the bone marrow and affect the production of blood cells

Causes of bone marrow diseases include genetics and environmental factors. Tests for bone marrow diseases include blood and bone marrow tests. Treatments depend on the disorder and how severe it is. They might involve medicines, blood transfusions or a bone marrow transplant.

Diagnosis and Tests

  • Blood Count Tests: MedlinePlus Health Topic From the National Institutes of Health (National Library of Medicine) Also in Spanish
  • Blood Tests From the National Institutes of Health (National Heart, Lung, and Blood Institute) Also in Spanish
  • Bone Marrow Test From the National Institutes of Health (National Library of Medicine) Also in Spanish
  • Reticulocyte Count From the National Institutes of Health (National Library of Medicine) Also in Spanish

Treatments and Therapies

  • Bone Marrow Transplantation: MedlinePlus Health Topic From the National Institutes of Health (National Library of Medicine) Also in Spanish
  • Drugs Approved for Myeloproliferative Neoplasms or Myelodysplastic Syndromes From the National Institutes of Health (National Cancer Institute)
  • Treatment Option Overview (Chronic Myeloproliferative Neoplasms) From the National Institutes of Health (National Cancer Institute) Also in Spanish
  • Treatment Option Overview (Myelodysplastic/Myeloproliferative Neoplasms) From the National Institutes of Health (National Cancer Institute) Also in Spanish

Specifics

  • Atypical Chronic Myelogenous Leukemia From the National Institutes of Health (National Cancer Institute) Also in Spanish
  • Essential Thrombocythemia From the National Institutes of Health (National Cancer Institute) Also in Spanish
  • General Information about Chronic Myeloproliferative Neoplasms From the National Institutes of Health (National Cancer Institute) Also in Spanish
  • General Information about Myelodysplastic/Myeloproliferative Neoplasms From the National Institutes of Health (National Cancer Institute) Also in Spanish
  • Juvenile Myelomonocytic Leukemia From the National Institutes of Health (National Cancer Institute) Also in Spanish
  • Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable From the National Institutes of Health (National Cancer Institute) Also in Spanish
  • Myelofibrosis (Mayo Foundation for Medical Education and Research) Also in Spanish
  • Polycythemia Vera (Mayo Foundation for Medical Education and Research) Also in Spanish
  • Primary Myelofibrosis From the National Institutes of Health (National Cancer Institute) Also in Spanish
  • Thrombocythemia and Thrombocytosis From the National Institutes of Health (National Heart, Lung, and Blood Institute) Also in Spanish

Genetics

  • 8p11 myeloproliferative syndrome: MedlinePlus Genetics From the National Institutes of Health (National Library of Medicine)
  • Ataxia-pancytopenia syndrome: MedlinePlus Genetics From the National Institutes of Health (National Library of Medicine)
  • Diamond-Blackfan anemia: MedlinePlus Genetics From the National Institutes of Health (National Library of Medicine)
  • Essential thrombocythemia: MedlinePlus Genetics From the National Institutes of Health (National Library of Medicine)
  • Fanconi anemia: MedlinePlus Genetics From the National Institutes of Health (National Library of Medicine)
  • Paroxysmal nocturnal hemoglobinuria: MedlinePlus Genetics From the National Institutes of Health (National Library of Medicine)
  • Pearson marrow-pancreas syndrome: MedlinePlus Genetics From the National Institutes of Health (National Library of Medicine)
  • Polycythemia vera: MedlinePlus Genetics From the National Institutes of Health (National Library of Medicine)
  • Primary myelofibrosis: MedlinePlus Genetics From the National Institutes of Health (National Library of Medicine)
  • Shwachman-Diamond syndrome: MedlinePlus Genetics From the National Institutes of Health (National Library of Medicine)

Clinical Trials

  • ClinicalTrials.gov: Bone Marrow Diseases From the National Institutes of Health (National Institutes of Health)
  • ClinicalTrials.gov: Myeloproliferative Disorders From the National Institutes of Health (National Institutes of Health)

Journal Articles References and abstracts from MEDLINE/PubMed (National Library of Medicine)

  • Article: Clinical usefulness of next-generation sequencing-based target gene sequencing in diagnosis of...
  • Article: Bone marrow lesions and collateral ligament lesions are associated in interphalangeal...
  • Article: Bone marrow lesions related to bone marrow edema syndromes and osteonecrosis.
  • Bone Marrow Diseases -- see more articles

Find an Expert

  • American Cancer Society
  • Leukemia & Lymphoma Society Also in Spanish
  • National Cancer Institute From the National Institutes of Health Also in Spanish
  • National Heart, Lung, and Blood Institute From the National Institutes of Health

Children

  • Diamond-Blackfan Anemia (For Parents) (Nemours Foundation) Also in Spanish

Patient Handouts

  • Bone marrow aspiration (Medical Encyclopedia) Also in Spanish
  • Bone marrow culture (Medical Encyclopedia) Also in Spanish
  • Bone marrow transplant (Medical Encyclopedia) Also in Spanish
  • Bone marrow transplant - discharge (Medical Encyclopedia) Also in Spanish
  • Myelofibrosis (Medical Encyclopedia) Also in Spanish
  • Polycythemia vera (Medical Encyclopedia) Also in Spanish

Topic Image

Bone Marrow Diseases

MEDICAL ENCYCLOPEDIA

  • Agranulocytosis
  • Bone marrow aspiration
  • Bone marrow biopsy
  • Bone marrow culture
  • Bone marrow transplant
  • Bone marrow transplant - discharge
  • Bone-marrow transplant - series
  • Erythropoietin test
  • Myelofibrosis
  • Paroxysmal nocturnal hemoglobinuria (PNH)
  • Polycythemia vera
  • Reticulocyte count

Related Health Topics

  • Amyloidosis
  • Anemia
  • Aplastic Anemia
  • Bone Marrow Transplantation
  • Multiple Myeloma
  • Myelodysplastic Syndromes

National Institutes of Health

The primary NIH organization for research on Bone Marrow Diseases is the National Heart, Lung, and Blood Institute

Other Languages

Find health information in languages other than English on Bone Marrow Diseases

Disclaimers

MedlinePlus links to health information from the National Institutes of Health and other federal government agencies. MedlinePlus also links to health information from non-government Web sites. See our disclaimer about external links and our quality guidelines.

The information on this site should not be used as a substitute for professional medical care or advice. Contact a health care provider if you have questions about your health.

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