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Myelodysplastic Syndromes
URL of this page: https://medlineplus.gov/myelodysplasticsyndromes.html

Myelodysplastic Syndromes

Also called: MDS
On this page

Basics

  • Summary
  • Start Here
  • Diagnosis and Tests
  • Prevention and Risk Factors
  • Treatments and Therapies

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  • Related Issues
  • Specifics
  • Genetics

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Summary

Your bone marrow is the spongy tissue inside some of your bones, such as your hip and thigh bones. It contains immature cells, called stem cells. The stem cells can develop into the red blood cells that carry oxygen through your body, the white blood cells that fight infections, and the platelets that help with blood clotting. If you have a myelodysplastic syndrome, the stem cells do not mature into healthy blood cells. Many of them die in the bone marrow. This means that you do not have enough healthy cells, which can lead to infection, anemia, or easy bleeding.

Myelodysplastic syndromes often do not cause early symptoms and are sometimes found during a routine blood test. If you have symptoms, they may include:

  • Shortness of breath
  • Weakness or feeling tired
  • Skin that is paler than usual
  • Easy bruising or bleeding
  • Pinpoint spots under the skin caused by bleeding
  • Fever or frequent infections

Myelodysplastic syndromes are rare. People at higher risk are over 60, have had chemotherapy or radiation therapy, or have been exposed to certain chemicals. Treatment options include transfusions, drug therapy, chemotherapy, and blood or bone marrow stem cell transplants.

NIH: National Cancer Institute

Start Here

  • General Information about Myelodysplastic Syndromes From the National Institutes of Health (National Cancer Institute)
  • General Information about Myelodysplastic/Myeloproliferative Neoplasms From the National Institutes of Health (National Cancer Institute) Also in Spanish
  • Myelodysplastic Syndromes (Mayo Foundation for Medical Education and Research)
  • Myelodysplastic Syndromes (MDS) (National Marrow Donor Program)
  • What Are Myelodysplastic Syndromes? (American Cancer Society) Also in Spanish

Diagnosis and Tests

  • Blood Tests From the National Institutes of Health (National Heart, Lung, and Blood Institute) Also in Spanish
  • Bone Marrow Test From the National Institutes of Health (National Library of Medicine) Also in Spanish
  • How Is Chronic Myelomonocytic Leukemia Diagnosed? (American Cancer Society)
  • Myelodysplastic Syndrome Prognostic Scores (American Cancer Society) Also in Spanish
  • Tests for Myelodysplastic Syndromes (American Cancer Society) Also in Spanish

Prevention and Risk Factors

  • Can Myelodysplastic Syndromes Be Prevented? (American Cancer Society) Also in Spanish
  • Risk Factors for Myelodysplastic Syndromes (American Cancer Society) Also in Spanish

Treatments and Therapies

  • Bone Marrow Transplantation: MedlinePlus Health Topic From the National Institutes of Health (National Library of Medicine) Also in Spanish
  • General Approach to Treatment of Chronic Myelomonocytic Leukemia (American Cancer Society)
  • Treatment of Myelodysplastic Syndromes From the National Institutes of Health (National Cancer Institute) Also in Spanish
  • Treatment Option Overview (Myelodysplastic Syndromes) From the National Institutes of Health (National Cancer Institute) Also in Spanish
  • Treatment Option Overview (Myelodysplastic/Myeloproliferative Neoplasms) From the National Institutes of Health (National Cancer Institute) Also in Spanish

Related Issues

  • Aplastic Anemia and Myelodysplastic Syndromes From the National Institutes of Health (National Institute of Diabetes and Digestive and Kidney Diseases)
  • What Causes Myelodysplastic Syndromes? (American Cancer Society) Also in Spanish

Specifics

  • Juvenile Myelomonocytic Leukemia From the National Institutes of Health (National Cancer Institute) Also in Spanish
  • Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable From the National Institutes of Health (National Cancer Institute) Also in Spanish
  • Types of Myelodysplastic Syndromes (American Cancer Society) Also in Spanish
  • What Is Chronic Myelomonocytic Leukemia? (American Cancer Society)

Genetics

  • 5q minus syndrome: MedlinePlus Genetics From the National Institutes of Health (National Library of Medicine)
  • Do We Know What Causes Chronic Myelomonocytic Leukemia? (American Cancer Society)

Statistics and Research

  • Statistics about Myelodysplastic Syndromes (American Cancer Society) Also in Spanish
  • What's New in Myelodysplastic Syndrome Research? (American Cancer Society) Also in Spanish

Clinical Trials

  • ClinicalTrials.gov: Myelodysplastic Syndromes From the National Institutes of Health (National Institutes of Health)

Journal Articles References and abstracts from MEDLINE/PubMed (National Library of Medicine)

  • Article: Prognostic impact of somatic mutations and additional chromosomal abnormalities in patients...
  • Article: Luspatercept for the treatment of lower-risk myelodysplastic syndrome with SF3B1 mutation:...
  • Article: A non-genotoxic stem cell therapy boosts lymphopoiesis and averts age-related blood...
  • Myelodysplastic Syndromes -- see more articles

Find an Expert

  • American Cancer Society
  • National Cancer Institute From the National Institutes of Health Also in Spanish
  • National Heart, Lung, and Blood Institute From the National Institutes of Health

Patient Handouts

  • Bone marrow transplant (Medical Encyclopedia) Also in Spanish
  • Bone marrow transplant - discharge (Medical Encyclopedia) Also in Spanish

Topic Image

Myelodysplastic Syndromes

MEDICAL ENCYCLOPEDIA

  • Bone marrow transplant
  • Bone marrow transplant - discharge
  • Bone-marrow transplant - series
  • Myelodysplastic syndrome

Related Health Topics

  • Bone Marrow Diseases

National Institutes of Health

The primary NIH organization for research on Myelodysplastic Syndromes is the National Cancer Institute

Disclaimers

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The information on this site should not be used as a substitute for professional medical care or advice. Contact a health care provider if you have questions about your health.

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