When you have an allergic reaction to a substance, your body releases histamine and other chemicals into the blood. This causes itching, swelling, and other symptoms. Hives are a common reaction. People with other allergies, such as hay fever, often get hives.

Angioedema is swelling of the deeper tissue that sometimes occurs with hives. Like hives, angioedema can occur on any part of the body. When it occurs around the mouth or throat, the symptoms can be severe, including airway blockage.

Many substances can trigger hives, including:

• Animal dander (especially cats)
• Insect bites
• Medicines
• Pollen
• Shellfish, fish, nuts, eggs, milk, and other foods

Hives may also develop as a result of:

• Emotional stress
• Extreme cold or sun exposure
• Excessive perspiration
• Illness, including lupus, other autoimmune diseases, and leukemia
• Infections such as mononucleosis
• Exercise
• Exposure to water

Often, the cause of hives is not known.

Symptoms of hives may include any of the following:

• Itching.
• Swelling of the surface of the skin into red- or skin-colored welts (called wheals) with clearly defined edges.
• Wheals may get bigger, spread, and join together to form larger areas of flat, raised skin.
• Wheals often change shape, disappear, and reappear within minutes or hours. It is unusual for a wheal to last more than 48 hours.
• Dermatographism, or skin writing, is a type of hives. It is caused by pressure on the skin and results in immediate hives in the area that has been pressed on or scratched.

Your health care provider can tell if you have hives by looking at your skin.

If you have a history of an allergy causing hives, for example, to strawberries, the diagnosis is even clearer.

Sometimes, a skin biopsy or blood tests are done to confirm that you had an allergic reaction, and to test for the substance that caused the allergic response. However, specific allergy testing is not useful in most cases of hives.

Treatment may not be needed if the hives are mild. They may disappear on their own. To reduce itching and swelling:

• Do not take hot baths or showers.
• Do not wear tight-fitting clothing, which can irritate the area.
• Your provider may suggest that you take an antihistamine such as diphenhydramine (Benadryl) or cetirizine (Zyrtec). Follow your provider's instructions or the package instructions about how to take the medicine.
• Other oral prescription medicines may be needed, especially if the hives are chronic (long-lasting).

If your reaction is severe, especially if the swelling involves your throat, you may need an emergency shot of epinephrine (adrenaline) or steroids. Hives in the throat can block your airway, making it difficult to breathe.

Hives may be uncomfortable, but they are usually harmless and disappear on their own.

When the condition lasts longer than 6 weeks, it is called chronic hives. Usually no cause can be found. Most chronic hives resolve on their own in less than 1 year.

Complications of hives may include:

• Anaphylaxis (a life-threatening, whole-body allergic reaction that causes breathing difficulty)
• Swelling in the throat can lead to life-threatening airway blockage

Call 911 or the local emergency number if you have:

• Fainting
• Shortness of breath
• Tightness in your throat
• Tongue or face swelling
• Wheezing

Call your provider if the hives are severe, uncomfortable, and do not respond to self-care measures.

To help prevent hives, avoid exposure to substances that give you allergic reactions.

Urticaria - hives; Wheals

Dinulos JGH. Urticaria, angioedema, and pruritus. In: Dinulos JGH, ed. Habif's Clinical Dermatology. 7th ed. Philadelphia, PA: Elsevier; 2021:chap 6.

James WD, Elston DM, Treat JR, Rosenbach MA, Neuhaus IM. Erythema and urticaria. In: James WD, Elston DM, Treat JR, Rosenbach MA, Neuhaus IM, eds. Andrews' Diseases of the Skin: Clinical Dermatology. 13th ed. Philadelphia, PA: Elsevier; 2020:chap 7.

Updated by: Ramin Fathi, MD, FAAD, Director, Phoenix Surgical Dermatology Group, Phoenix, AZ. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.