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• Summary
• Start Here
• Diagnosis and Tests
• Learn More
• Treatments and Therapies

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• Related Issues
• Specifics
• Genetics

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• Clinical Trials
• Journal Articles

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Summary

Most of the time, medicines make our lives better. They reduce aches and pains, fight infections, and control problems such as high blood pressure or diabetes. But medicines can also cause unwanted reactions, such as drug interactions, side effects, and allergies.

What is a drug interaction?

A drug interaction is a change in the way a drug acts in the body when taken with certain other drugs, foods, or supplements or when taken while you have certain medical conditions. Examples include:

• Two drugs, such as aspirin and blood thinners
• Drugs and food, such as statins and grapefruit
• Drugs and supplements, such as gingko and blood thinners
• Drugs and medical conditions, such as aspirin and peptic ulcers

Interactions could cause a drug to be more or less effective, cause side effects, or change the way one or both drugs work.

What are side effects?

Side effects are unwanted, usually unpleasant, effects caused by medicines. Most are mild, such as a stomachache, dry mouth, or drowsiness, and go away after you stop taking the medicine. Others can be more serious. Sometimes a drug can interact with a disease that you have and cause a side effect. For example, if you have a heart condition, certain decongestants can cause you to have a rapid heartbeat.

What are drug allergies?

Drug allergies are another type of reaction. They can range from mild to life-threatening. Skin reactions, such as hives and rashes, are the most common type. Anaphylaxis, a serious allergic reaction, is less common.

How can I stay safe when taking medicines?

When you start a new prescription or over-the-counter medicine, make sure you understand how to take it correctly. Know which other medicines, foods, and supplements you need to avoid. Always talk to your health care provider or pharmacist if you have questions about your medicines.

Start Here

• Drug Allergy (Mayo Foundation for Medical Education and Research) Also in Spanish
• Drug Interactions: What You Should Know (Food and Drug Administration) Also in Spanish
• Drug Reactions (American Academy of Family Physicians) Also in Spanish
• Medications and Drug Allergic Reactions (American Academy of Allergy, Asthma, and Immunology) Also in Spanish

Diagnosis and Tests

• Allergy Skin Test (National Library of Medicine) Also in Spanish
• Anaphylaxis (American Academy of Allergy, Asthma, and Immunology) Also in Spanish
• Anaphylaxis-Like Reactions (National Jewish Health)
• Pharmacogenetic Tests (National Library of Medicine) Also in Spanish
• Pharmacogenetics: How Genetic Testing Can Guide Medicine Decisions (Nemours Foundation) Also in Spanish
• Therapeutic Drug Monitoring (National Library of Medicine) Also in Spanish

Learn More

• Drug Allergies: What to Look Out For (National Institutes of Health) Also in Spanish
• Medication/Drug Allergy (National Jewish Health)

Treatments and Therapies

• Anaphylaxis: First Aid (Mayo Foundation for Medical Education and Research) Also in Spanish

Related Issues

• Drug-Food Interactions (American Academy of Family Physicians) Also in Spanish
• Drug-Nutrient Interactions and Drug-Supplement Interactions: Examples of Dietary Supplement Interactions (American Academy of Family Physicians) Also in Spanish
• FDA Pharmacists Help You Use Medicines Safely (Food and Drug Administration) Also in Spanish
• Harmful Interactions: Mixing Alcohol with Medicines (National Institute on Alcohol Abuse and Alcoholism) Also in Spanish
• Know the Science: How Medications and Supplements Can Interact (National Center for Complementary and Integrative Health)
• Medication Interactions: Food, Supplements, and Other Drugs (American Heart Association)
• MedWatch, the FDA Safety Information and Adverse Event Reporting Program (Food and Drug Administration)
• OTC Medicines: Know Your Risks and Reduce Them (American Academy of Family Physicians) Also in Spanish

Specifics

• Aspirin Allergy: What Are the Symptoms? (Mayo Foundation for Medical Education and Research) Also in Spanish
• Grapefruit Juice and Some Drugs Don't Mix (Food and Drug Administration) Also in Spanish
• Neuroleptic Malignant Syndrome (National Institute of Neurological Disorders and Stroke)
• Penicillin Allergy (Mayo Foundation for Medical Education and Research) Also in Spanish
• Sulfa Allergy: Which Medications Should I Avoid? (Mayo Foundation for Medical Education and Research) Also in Spanish

Genetics

• Stevens-Johnson syndrome/toxic epidermal necrolysis: MedlinePlus Genetics (National Library of Medicine)
• Thiopurine S-methyltransferase deficiency: MedlinePlus Genetics (National Library of Medicine)

Images

• Drug Eruption (VisualDX)

Clinical Trials

• ClinicalTrials.gov: Drug Hypersensitivity (National Institutes of Health)
• ClinicalTrials.gov: Drug Interactions (National Institutes of Health)
• ClinicalTrials.gov: Drug-Related Side Effects and Adverse Reactions (National Institutes of Health)

Journal Articles References and abstracts from MEDLINE/PubMed (National Library of Medicine)

• Article: Impact of medication nonadherence and drug-drug interaction testing on the management...
• Article: Evaluation of drug-drug interactions of a novel potent FLT3 inhibitor SKLB1028...
• Article: Clinical Assessment of Breast Cancer Resistance Protein (BCRP)-Mediated Drug-Drug Interactions of...
• Drug Reactions -- see more articles

Reference Desk

• MedlinePlus: Drug Information (National Library of Medicine) - Information on prescription and over-the-counter medicines and supplements Also in Spanish

Find an Expert

• Food and Drug Administration

Children

• Drug Eruption (Pediatric) (VisualDX)
• Penicillin Allergy (For Parents) (Nemours Foundation) Also in Spanish

Older Adults

• Medications Older Adults Should Avoid or Use With Caution (AGS Health in Aging Foundation)

Patient Handouts

• Angioedema (Medical Encyclopedia) Also in Spanish
• Drug allergies (Medical Encyclopedia) Also in Spanish
• Drug-induced diarrhea (Medical Encyclopedia) Also in Spanish
• Drug-induced tremor (Medical Encyclopedia) Also in Spanish
• Taking multiple medicines safely (Medical Encyclopedia) Also in Spanish