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Statins
URL of this page: https://medlineplus.gov/statins.html

Statins

Also called: HMG-CoA reductase inhibitors
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Summary

What is cholesterol?

Cholesterol is a waxy, fat-like substance that's found in all the cells in your body. Your body needs some cholesterol to work properly. But if you have too much of it in your blood, it can stick to the walls of your arteries and narrow or even block them. This puts you at risk for coronary artery disease and other heart diseases.

Cholesterol is made by your liver. It travels through the blood on proteins called lipoproteins. One type of lipoprotein, LDL, is sometimes called the "bad" cholesterol. A high LDL level leads to a buildup of cholesterol in your arteries. Another type, HDL, is sometimes called the "good" cholesterol. It carries cholesterol from other parts of your body back to your liver. Then your liver removes the cholesterol from your body.

What are statins?

Statins are a type of cholesterol medicine. Your health care provider may prescribe them if you have high cholesterol and making lifestyle changes does not lower your cholesterol enough. Statins are the most common medicines used to treat high cholesterol.

How do statins lower cholesterol?

Statins lower LDL cholesterol by slowing down how much cholesterol the liver makes. They also increase your liver's ability to remove LDL cholesterol that is already in the blood. This can slow the formation of plaques in your arteries. Studies have shown that statins lower the risk of heart attack and stroke in people with high LDL cholesterol.

Statins can lower your triglyceride level as well. Triglycerides are another type of fat in your blood that can raise the risk of heart disease. Statins may also increase your HDL cholesterol.

What are the risks of taking statins?

Statins usually don't cause side effects, but they may raise the risk of type 2 diabetes. However, this mainly happens in people already at high risk of diabetes, such as those who are overweight or have obesity, prediabetes, or metabolic syndrome.

Statins may also cause abnormal results on liver enzymes tests, but actual liver damage is very rare. Another uncommon side effect is muscle damage. In rare cases, this muscle damage can lead to muscle pain and kidney damage.

You should not take statins if you are pregnant or breastfeeding. They are also not recommended for people who have certain types of liver disease.

How can I safely take statins?

To safely take statins, you should:

  • Take your statin as prescribed. You should not stop taking this medicine on your own, since that can lead to a serious problem or, in rare cases, even cause death. Talk to your provider if you have any concerns about your statin or if you would like to stop or change to a different treatment.
  • Ask your provider which other medicines, supplements, or foods you should avoid. Some of these can interact with statins and cause serious side effects or make statins less effective. For example, grapefruit (fresh or as juice) affects how your liver breaks down some statins.
  • Tell your provider about any symptoms or side effects you are having. Sometimes, people report muscle problems while taking statins. If you start having muscle pain, your provider may order a blood test to look look for muscle damage. The pain may go away if you switch to a different statin. Muscle damage with statins is rare, and your muscles may heal when you switch to a different medicine.

Start Here

  • Statins: Are These Cholesterol-Lowering Drugs Right for You? (Mayo Foundation for Medical Education and Research) Also in Spanish

Diagnosis and Tests

  • Pharmacogenetic Tests From the National Institutes of Health (National Library of Medicine) Also in Spanish

Related Issues

  • Cholesterol-Lowering Medicines (Centers for Disease Control and Prevention)
  • Rhabdomyolysis from Statins: What's the Risk? (Mayo Foundation for Medical Education and Research) Also in Spanish
  • Statin Side Effects: Weigh the Benefits and Risks (Mayo Foundation for Medical Education and Research) Also in Spanish
  • Statins: Do They Cause ALS? (Mayo Foundation for Medical Education and Research) Also in Spanish

Statistics and Research

  • Cholesterol Drug May Help Protect the Heart during Chemotherapy for Lymphoma From the National Institutes of Health (National Cancer Institute)

Clinical Trials

  • ClinicalTrials.gov: Hydroxymethylglutaryl-CoA Reductase Inhibitors From the National Institutes of Health (National Institutes of Health)

Journal Articles References and abstracts from MEDLINE/PubMed (National Library of Medicine)

  • Article: Randomized Controlled Trial of Atorvastatin in Acute Influenza in the Emergency...
  • Article: Efficacy of Atorvastatin Against Venous Thromboembolism After Total Hip Arthroplasty.
  • Article: Statin Therapy as Primary Prevention for Persons With HIV: A Synopsis...
  • Statins -- see more articles

Find an Expert

  • American Heart Association
  • Food and Drug Administration
  • National Heart, Lung, and Blood Institute From the National Institutes of Health

Patient Handouts

  • Cholesterol - drug treatment (Medical Encyclopedia) Also in Spanish
  • How to take statins (Medical Encyclopedia) Also in Spanish

Topic Image

Statins

MEDICAL ENCYCLOPEDIA

  • Cholesterol - drug treatment
  • How to take statins

Related Health Topics

  • Cholesterol
  • Cholesterol Medicines
  • HDL: The "Good" Cholesterol
  • LDL: The "Bad" Cholesterol

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The information on this site should not be used as a substitute for professional medical care or advice. Contact a health care provider if you have questions about your health.

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