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Scleroderma
URL of this page: https://medlineplus.gov/scleroderma.html

Scleroderma

Also called: Circumscribed scleroderma, Dermatosclerosis, Morphea, Systemic sclerosis
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Summary

What is scleroderma?

Scleroderma means "hard skin." It's the name of an autoimmune disease that causes inflammation and thickening in the skin and other areas of the body. This inflammation causes you to have areas of tight, hard skin. Scleroderma may affect just one area of your body, or it can affect many systems in your body.

What are the types of scleroderma?

There are two main types of scleroderma:

  • Localized scleroderma only affects your skin and the muscles and tissues just under your skin.
  • Systemic scleroderma, which is also called systemic sclerosis, is a more serious type. It affects many parts of your body and can damage your blood vessels and internal organs, such as your heart, lungs, and kidneys.

What causes scleroderma?

The exact cause of scleroderma is unknown. Researchers think that several factors may play a part in causing the disease:

  • Your genetics. Certain genes can increase the chance that you will develop scleroderma. They may also play a role in which the type of scleroderma you have. Scleroderma is not passed from parent to child, but you are more likely to develop it if a close relative has it.
  • Your environment. Exposure to certain things in the environment, such as viruses or chemicals, may trigger scleroderma.
  • Immune system changes. When your immune system changes, it can trigger your cells to make too much collagen in the body. Too much collagen causes patches of tight, hard skin.
  • Hormones. Hormonal or immune system differences between women and men might play a part in the disease.

Who is more likely to develop scleroderma?

Anyone can get scleroderma, but certain factors may make you more likely to develop it:

  • Your sex. Scleroderma is more common in women than in men.
  • Your age. The disease usually appears between the ages of 30 and 50.
  • Your race. Scleroderma can affect people of all races and ethnic groups, but the disease can affect African Americans more severely.

What are the symptoms of scleroderma?

The symptoms of scleroderma are different for each person, depending on the type of scleroderma you have:

  • Localized scleroderma usually causes patches of thick, hard skin in one of two patterns:
    • Patches in firm, oval shapes that stay in one area or spread to other areas of skin. This is called morphea.
    • Lines of thickened or different colored skin that run down your arm, leg, and, rarely, on the forehead. This is called linear scleroderma.
  • Systemic scleroderma can cause problems with your internal organs as well as your skin. It can cause symptoms such as:
    • Thick, tight skin on your fingers
    • Fatigue
    • Raynaud's phenomenon, a narrowing of blood vessels in the hands or feet
    • Damage to your internal organs, including your digestive system, lungs, kidneys, and heart

How is scleroderma diagnosed?

There is no single test for scleroderma. The symptoms can vary from person to person and can be similar to those of other diseases. This can make scleroderma hard to diagnose.

To find out if you have scleroderma, your health care provider:

  • Will ask about your symptoms and medical history
  • Will do a physical exam
  • May order blood tests, including an ANA (antinuclear antibody) test
  • May do a skin biopsy
  • May do other tests, such as imaging tests, to check for organ damage

What are the treatments for scleroderma?

There is no cure for scleroderma, but treatments can help control your symptoms and limit damage. The treatments may include:

  • Medicines to help decrease swelling, manage pain, control other symptoms, and prevent complications.
  • Physical or occupational therapy to help with pain, improve muscle strength, and teach you ways to help with daily living.
  • Regular dental care, because scleroderma can make your mouth dry and damage connective tissues in your mouth. These problems can speed up tooth decay and cause your teeth to become loose.

You may need to see specialists to help treat your disease. Many people with scleroderma will see a rheumatologist. This is a doctor who specializes in rheumatic diseases such as arthritis and other inflammatory or autoimmune disorders. Dermatologists, who specialize in conditions of the skin, hair, and nails, may also play an important role in treating the disease. And if you have organ damage, you may need to see other specialists.

You can also help manage some of your symptoms, for example by:

  • Dressing warm and avoiding cold or wet environments
  • Quitting smoking (if you smoke)
  • Putting on sunscreen before you go outdoors
  • Using moisturizers on your skin to help lessen stiffness
  • Avoiding hot baths and showers, harsh soaps, and household cleaners
  • Getting regular physical activity

NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases

Start Here

  • Scleroderma (American College of Rheumatology) Also in Spanish
  • Scleroderma (Mayo Foundation for Medical Education and Research)
  • What Is Scleroderma? From the National Institutes of Health (National Institute of Arthritis and Musculoskeletal and Skin Diseases) Also in Spanish

Diagnosis and Tests

  • ANA (Antinuclear Antibody) Test From the National Institutes of Health (National Library of Medicine) Also in Spanish

Treatments and Therapies

  • Scleroderma Complications and Treatments (Scleroderma Research Foundation)

Related Issues

  • Dental Care in Scleroderma (National Scleroderma Foundation) - PDF

Specifics

  • Morphea (American Osteopathic College of Dermatology)

Genetics

  • Systemic scleroderma: MedlinePlus Genetics From the National Institutes of Health (National Library of Medicine)

Statistics and Research

  • Arthritis by the Numbers: Book of Trusted Facts and Figures (Arthritis Foundation) - PDF

Clinical Trials

  • ClinicalTrials.gov: Scleroderma, Localized From the National Institutes of Health (National Institutes of Health)
  • ClinicalTrials.gov: Scleroderma, Systemic From the National Institutes of Health (National Institutes of Health)

Journal Articles References and abstracts from MEDLINE/PubMed (National Library of Medicine)

  • Article: Mesenchymal Stem-Cell-Derived Exosomes and MicroRNAs: Advancing Cell-Free Therapy in Systemic Sclerosis.
  • Article: Understanding the Role of Epithelial Cells in the Pathogenesis of Systemic...
  • Article: Identification of serum exosome proteins in systemic sclerosis with interstitial lung...
  • Scleroderma -- see more articles

Find an Expert

  • Find a Rheumatologist (American College of Rheumatology)
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases From the National Institutes of Health Also in Spanish

Patient Handouts

  • Collagen vascular disease (Medical Encyclopedia) Also in Spanish
  • Scleroderma (Medical Encyclopedia) Also in Spanish
  • Swallowing problems (Medical Encyclopedia) Also in Spanish

Topic Image

Scleroderma

MEDICAL ENCYCLOPEDIA

  • Collagen vascular disease
  • Gastroparesis
  • Necrotizing vasculitis
  • Scleroderma
  • Swallowing problems

Related Health Topics

  • Raynaud Phenomenon

National Institutes of Health

The primary NIH organization for research on Scleroderma is the National Institute of Arthritis and Musculoskeletal and Skin Diseases

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The information on this site should not be used as a substitute for professional medical care or advice. Contact a health care provider if you have questions about your health.

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